Soma. CNS Depressants

The sedative results of carisoprodol and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) might be additive. Therefore, caution really should be exercised with sufferers who take much more than one particular of these CNS depressants simultaneously. Concomitant use of carisoprodol and meprobamate, a metabolite of carisoprodol, is not suggested.

Carisoprodol is metabolized in the liver by CYP2C19 to form meprobamate [see Medical Pharmacology. Co-administration of CYP2C19 inhibitors, this kind of as omeprazole or fluvoxamine, with carisoprodol could end result in greater exposure of carisoprodol and lowered exposure of meprobamate. Co-administration of CYP2C19 inducers, this sort of as rifampin or St. John’s Wort, with carisoprodol could final result in reduced exposure of carisoprodol and elevated exposure of meprobamate. Very low dose aspirin also showed an induction impact on CYP2C19. The total pharmacological influence of these likely alterations of exposures in conditions of possibly efficacy or basic safety of carisoprodol is unknown.

antibiotics

Soma Description

Carisoprodol Tablets, USP are offered as 350 mg round, white tablets for oral administration. Carisoprodol is a white, crystalline powder, having a mild, attribute odor and a bitter style. It is marginally soluble in water freely soluble in alcohol, in chloroform, and in acetone and its solubility is nearly independent of pH. Carisoprodol is current as a racemic mixture. Chemically, carisoprodol is N-isopropyl-2-methyl-two-propyl-one,three-propanediol dicarbamate and the molecular components is C12H24N2O4, with a molecular pounds of 260.33.

Soma Usage

Absorption: Absolute bioavailability of carisoprodol has not been established. The imply time to peak plasma concentrations (Tmax) of carisoprodol was approximately one.5 to 2 hrs. Co-administration of a large-body fat meal with carisoprodol (350 mg tablet) had no impact on the pharmacokinetics of carisoprodol. Therefore, carisoprodol may well be administered with or with out foods. The structural formula is: Other substances in Carisoprodol Tablets, USP incorporate croscarmellose sodium, hydrogenated vegetable oil, hypromellose, magnesium stearate and microcrystalline cellulose. Elimination:Carisoprodol is eradicated by the two renal and non-renal routes with a terminal elimination 50 percent-lifestyle of roughly two several hours. The fifty percent-existence of meprobamate is approximately ten hrs. Gender: Publicity of carisoprodol is greater in female than in male subjects (approximately 30-fifty% on a excess weight adjusted foundation). Total exposure of meprobamate is equivalent involving female and douleur subjects. 350 mg Tablets: white, round, unscored tablets debossed “WW 176” on one side and plain on the reverse side; available in bottles of 120, 45 and 90. Storage: Store at 20°-25°C (68°-77°F).